Version 5.4
Mus musculus Protein: Wiz
Summary
InnateDB Protein IDBP-165572.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wiz
Protein Name widely-interspaced zinc finger motifs
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000069443
InnateDB Gene IDBG-165568 (Wiz)
Protein Structure
UniProt Annotation
Function May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization. {ECO:0000269PubMed:16702210}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16702210}.
Disease Associations
Tissue Specificity According to PubMed:9795207, isoform L and isoform S are brain-specific. According to PubMed:16702210, isoform S is ubiquitously expressed. {ECO:0000269PubMed:16702210, ECO:0000269PubMed:9795207}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0070984 SET domain binding
Biological Process
GO:0010571 positive regulation of nuclear cell cycle DNA replication
GO:0050821 protein stabilization
GO:0070208 protein heterotrimerization
Cellular Component
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1332638
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88286
PhosphoSite PhosphoSite-O88286
TrEMBL E9Q5R9
UniProt Splice Variant
Entrez Gene 22404
UniGene Mm.488513
RefSeq NP_997603
MGI ID
MGI Symbol Wiz
OMIM
CCDS CCDS28617
HPRD
IMGT
EMBL AB012265 AB012266 AB255388 AK004274 AK133564 BC053035 CT033751 CT485616
GenPept AAH53035 BAA32790 BAA32791 BAB23245 BAE21728 BAE93139

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca