InnateDB Protein
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IDBP-165716.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Slc6a3
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Protein Name
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solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
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Synonyms
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DAT; Dat1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000022100
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InnateDB Gene
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IDBG-165714 (Slc6a3)
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Protein Structure
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Function |
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Found in the substantia nigra and ventral tegmental dopamine neurons, in fibers of the medial forebrain bundle ascending into the striatum, and within dense fiber networks and varicosities in the dorsal and ventral striatum. Lower expression in the cortex. Absent from the corpus callosum. {ECO:0000269PubMed:19357284}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
15 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:94862
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InterPro |
IPR000175
Sodium:neurotransmitter symporter
IPR002436
Sodium:neurotransmitter symporter, dopamine
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PFAM |
PF00209
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PRINTS |
PR00176
PR01202
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q61327
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PhosphoSite |
PhosphoSite-Q61327
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
13162
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UniGene |
Mm.41993
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RefSeq |
NP_034150
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MGI ID |
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MGI Symbol |
Slc6a3
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OMIM |
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CCDS |
CCDS26632
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HPRD |
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IMGT |
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EMBL |
AF109072
AH003328
BC054119
U16265
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GenPept |
AAA86462
AAC52283
AAD19643
AAH54119
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