InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ltb4r2

Summary

InnateDB Protein

IDBP-165773.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ltb4r2

Protein Name

leukotriene B4 receptor 2

Synonyms

5830462O07Rik; BLT2; LTB4-R 2; LTB4-R-2; LTB4-R2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048358

InnateDB Gene

IDBG-165771 (Ltb4r2)

Protein Structure

UniProt Annotation

Function

Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001632	leukotriene B4 receptor activity
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0051546	keratinocyte migration

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1888501

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR003981 Leukotriene B4 receptor
IPR003982 Leukotriene B4 type 2 receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR01476
PR01478

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JJL9