InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pik3ap1

Summary

InnateDB Protein

IDBP-165837.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pik3ap1

Protein Name

phosphoinositide-3-kinase adaptor protein 1

Synonyms

1810044J04Rik; BCAP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000052777

InnateDB Gene

IDBG-165835 (Pik3ap1)

Protein Structure

UniProt Annotation

Function

Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269PubMed:11781242, ECO:0000269PubMed:11877477, ECO:0000269PubMed:12833156, ECO:0000269PubMed:18025150, ECO:0000269PubMed:18337558, ECO:0000269PubMed:22187458, ECO:0000269PubMed:22187460}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:22187458}. Cell membrane {ECO:0000305PubMed:22187458}; Peripheral membrane protein {ECO:0000305PubMed:22187458}.

Disease Associations

Tissue Specificity

Predominantly expressed in spleen (at protein level). Expressed at lower levels in thymus, liver and lung. Expressed in B-cells, macrophages and natural killer (NK) cells. {ECO:0000269PubMed:11163197, ECO:0000269PubMed:18337558}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding
GO:0042802	identical protein binding

Biological Process

GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0034123	positive regulation of toll-like receptor signaling pathway
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034154	toll-like receptor 7 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0050727	regulation of inflammatory response