Version 5.4
Mus musculus Protein: Slc16a2
Summary
InnateDB Protein IDBP-165881.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc16a2
Protein Name solute carrier family 16 (monocarboxylic acid transporters), member 2
Synonyms AW105741; Mct8; Xpct;
Species Mus musculus
Ensembl Protein ENSMUSP00000037629
InnateDB Gene IDBG-165879 (Slc16a2)
Protein Structure
UniProt Annotation
Function Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in liver and kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0015293 symporter activity
Biological Process
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1203732
InterPro IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain
PFAM PF07690
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O70324
PhosphoSite PhosphoSite-O70324
TrEMBL Q05BA2
UniProt Splice Variant
Entrez Gene 20502
UniGene Mm.475003
RefSeq NP_033223
MGI ID
MGI Symbol Slc16a2
OMIM
CCDS CCDS30330
HPRD
IMGT
EMBL AB265788 AF045692 AJ421478 AL671187 BC080678 BC096587
GenPept AAC40078 AAH80678 AAH96587 BAF64537 CAD33931

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca