InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nfatc4

Summary

InnateDB Protein

IDBP-166065.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfatc4

Protein Name

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

Synonyms

3110041H08Rik; AW107667; AW546455; Nfat3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024179

InnateDB Gene

IDBG-166063 (Nfatc4)

Protein Structure

UniProt Annotation

Function

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL- 4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation (By similarity). May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons. {ECO:0000250UniProtKB:Q14934, ECO:0000269PubMed:17198697, ECO:0000269PubMed:18354019, ECO:0000269PubMed:9568714}.

Subcellular Localization

Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin- mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in all tissues analyzed including brain, lung, heart, testis and muscle. {ECO:0000269PubMed:18675896}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0042975	peroxisome proliferator activated receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001569	patterning of blood vessels
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007507	heart development
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0032760	positive regulation of tumor necrosis factor production
GO:0034644	cellular response to UV
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045333	cellular respiration
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048167	regulation of synaptic plasticity
GO:0051145	smooth muscle cell differentiation
GO:0055001	muscle cell development
GO:0071285	cellular response to lithium ion
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0045111	intermediate filament cytoskeleton

Protein Structure and Domains

PDB ID

MGI:1920431

InterPro

IPR002909 IPT domain
IPR008366 Nuclear factor of activated T cells (NFAT)
IPR008967 p53-like transcription factor, DNA-binding
IPR011539 Rel homology domain
IPR014756 Immunoglobulin E-set

PFAM

PF01833
PF00554

PRINTS

PR01789

PIRSF

SMART

SM00429

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt