Version 5.4
Mus musculus Protein: Cenpm
Summary
InnateDB Protein IDBP-166441.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cenpm
Protein Name centromere protein M
Synonyms 2610019I03Rik; AI853711; Pane1;
Species Mus musculus
Ensembl Protein ENSMUSP00000086560
InnateDB Gene IDBG-166437 (Cenpm)
Protein Structure
UniProt Annotation
Function Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:12881717}. Cytoplasm {ECO:0000269PubMed:12881717}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells. Localizes in the kinetochore domain of centromeres (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1913820
InterPro IPR020987 Centromere protein Cenp-M
PFAM PF11111
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CQA0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 66570
UniGene Mm.23596
RefSeq NP_079915
MGI ID
MGI Symbol Cenpm
OMIM
CCDS CCDS27685
HPRD
IMGT
EMBL AK010885 AK011191 AK011227 AK011464 AK011755 AK017679 AK168203 AY243536 AY243537 BC009160
GenPept AAH09160 AAO62567 AAO62568 BAB27246 BAB27456 BAB27479 BAB27635 BAB27823 BAB30869 BAE40163

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca