InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lias

Summary

InnateDB Protein

IDBP-166565.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lias

Protein Name

lipoic acid synthetase

Synonyms

2900022L22Rik; 4933425M12Rik; 7a5ex; C77512; mLip1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031101

InnateDB Gene

IDBG-166563 (Lias)

Protein Structure

UniProt Annotation

Function

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. {ECO:0000305}.

Subcellular Localization

Mitochondrion {ECO:0000255HAMAP- Rule:MF_03123, ECO:0000269PubMed:11389890}.

Disease Associations

Tissue Specificity

Expressed predominantly in heart, testis, and liver. {ECO:0000269PubMed:11389890}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0016992	lipoate synthase activity
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0001843	neural tube closure
GO:0006954	inflammatory response
GO:0006979	response to oxidative stress
GO:0009107	lipoate biosynthetic process
GO:0009249	protein lipoylation
GO:0032496	response to lipopolysaccharide