Version 5.4
Mus musculus Protein: Naga
Summary
InnateDB Protein IDBP-166694.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Naga
Protein Name N-acetyl galactosaminidase, alpha
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000023088
InnateDB Gene IDBG-166692 (Naga)
Protein Structure
UniProt Annotation
Function Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids (By similarity). {ECO:0000250}.
Subcellular Localization Lysosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004557 alpha-galactosidase activity
GO:0008456 alpha-N-acetylgalactosaminidase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0009311 oligosaccharide metabolic process
GO:0016052 carbohydrate catabolic process
GO:0016139 glycoside catabolic process
GO:0019377 glycolipid catabolic process
GO:0046477 glycosylceramide catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1261422
InterPro IPR000111 Glycoside hydrolase, clan GH-D
IPR002241 Glycoside hydrolase, family 27
IPR017853 Glycoside hydrolase, superfamily
PFAM PF02065
PRINTS PR00740
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QWR8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 17939
UniGene
RefSeq NP_032695
MGI ID
MGI Symbol Naga
OMIM
CCDS CCDS27686
HPRD
IMGT
EMBL AF079458 AJ223966 AK077116 AY079439 AY079440 BC021631
GenPept AAC28851 AAH21631 AAL87527 AAL87528 BAC36620 CAA11703

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca