InnateDB Protein
|
IDBP-166873.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Tppp
|
Protein Name
|
tubulin polymerization promoting protein
|
Synonyms
|
2900041A09Rik; AI849835;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000022057
|
InnateDB Gene
|
IDBG-166871 (Tppp)
|
Protein Structure
|
|
Function |
May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown. {ECO:0000269PubMed:18028908}.
|
Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:18028908}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:18028908}. Nucleus {ECO:0000269PubMed:18028908}.
|
Disease Associations |
|
Tissue Specificity |
Widely expressed with higher expression in brain (at protein level). {ECO:0000269PubMed:18028908}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
6 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1920198
|
InterPro |
IPR008907
P25-alpha
|
PFAM |
PF05517
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q7TQD2
|
PhosphoSite |
PhosphoSite-Q7TQD2
|
TrEMBL |
Q3URG1
|
UniProt Splice Variant |
|
Entrez Gene |
72948
|
UniGene |
Mm.416600
|
RefSeq |
NP_878259
|
MGI ID |
|
MGI Symbol |
Tppp
|
OMIM |
|
CCDS |
CCDS26638
|
HPRD |
|
IMGT |
|
EMBL |
AK141543
BC054803
CH466563
|
GenPept |
AAH54803
BAE24727
EDL37081
|
|
|