InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pdcd6

Summary

InnateDB Protein

IDBP-167309.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdcd6

Protein Name

programmed cell death 6

Synonyms

alg-2; Alg2; AV299538; MA-3; PS2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022060

InnateDB Gene

IDBG-167307 (Pdcd6)

Protein Structure

UniProt Annotation

Function

Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101 (By similarity). May mediate Ca(2+)-regulated signals along the death pathway. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Isoform 2 has a lower Ca(2+) affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5. {ECO:0000250, ECO:0000269PubMed:10744743, ECO:0000269PubMed:17889823}.

Subcellular Localization

Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Endosome {ECO:0000250}. Note=Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus. Translocated from the cytoplasm to the nucleus after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004198	calcium-dependent cysteine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046983	protein dimerization activity
GO:0048306	calcium-dependent protein binding
GO:0060090	binding, bridging

Biological Process

GO:0001525	angiogenesis
GO:0001938	positive regulation of endothelial cell proliferation
GO:0006508	proteolysis
GO:0006886	intracellular protein transport
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010595	positive regulation of endothelial cell migration
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032007	negative regulation of TOR signaling
GO:0034605	cellular response to heat
GO:0036324	vascular endothelial growth factor receptor-2 signaling pathway
GO:0045766	positive regulation of angiogenesis
GO:0051592	response to calcium ion
GO:0051898	negative regulation of protein kinase B signaling

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0031410	cytoplasmic vesicle
GO:0031965	nuclear membrane
GO:0070062	extracellular vesicular exosome