InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sdha

Summary

InnateDB Protein

IDBP-167331.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sdha

Protein Name

succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

Synonyms

1500032O14Rik; 2310034D06Rik; 4921513A11; C81073; FP; SDH2; SDHF;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022062

InnateDB Gene

IDBG-167329 (Sdha)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	60 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000104	succinate dehydrogenase activity
GO:0005515	protein binding
GO:0008177	succinate dehydrogenase (ubiquinone) activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006105	succinate metabolic process
GO:0007399	nervous system development
GO:0022900	electron transport chain
GO:0022904	respiratory electron transport chain
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005749	mitochondrial respiratory chain complex II

Protein Structure and Domains

PDB ID

MGI:1914195

InterPro

IPR003953 FAD binding domain
IPR011281 Succinate dehydrogenase, flavoprotein subunit
IPR014006 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal
IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain

PFAM

PF00890
PF02910

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K2B3

PhosphoSite