Version 5.4
Mus musculus Protein: Pram1
Summary
InnateDB Protein IDBP-167528.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pram1
Protein Name PML-RAR alpha-regulated adaptor molecule 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000057065
InnateDB Gene IDBG-167526 (Pram1)
Protein Structure
UniProt Annotation
Function May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P. {ECO:0000269PubMed:15572693}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in bone marrow and mature neutrophils. Weakly expressed in macrophages and mast cells. {ECO:0000269PubMed:15572693}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0007229 integrin-mediated signaling pathway
GO:0043313 regulation of neutrophil degranulation
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID MGI:3576625
InterPro IPR001452 SH3 domain
PFAM PF00018
PF14604
PRINTS PR00452
PIRSF
SMART SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6BCL1
PhosphoSite PhosphoSite-Q6BCL1
TrEMBL
UniProt Splice Variant
Entrez Gene 378460
UniGene Mm.272606
RefSeq NP_001002842
MGI ID
MGI Symbol Pram1
OMIM
CCDS CCDS37569
HPRD
IMGT
EMBL AY665714 CT033847
GenPept AAT76049

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca