InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mcm2

Summary

InnateDB Protein

IDBP-167537.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mcm2

Protein Name

minichromosome maintenance deficient 2 mitotin (S. cerevisiae)

Synonyms

AA959861; AW476101; BM28; CDCL1; Mcmd2; mKIAA0030;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000061923

InnateDB Gene

IDBG-167535 (Mcm2)

Protein Structure

UniProt Annotation

Function

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 81 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	81 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0003688	DNA replication origin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016851	magnesium chelatase activity
GO:0016887	ATPase activity
GO:0042393	histone binding
GO:0046872	metal ion binding

Biological Process

GO:0006260	DNA replication
GO:0006268	DNA unwinding involved in DNA replication
GO:0006270	DNA replication initiation
GO:0006334	nucleosome assembly
GO:0007049	cell cycle
GO:0015979	photosynthesis
GO:0015995	chlorophyll biosynthetic process
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005664	nuclear origin of replication recognition complex
GO:0005737	cytoplasm
GO:0015630	microtubule cytoskeleton
GO:0042555	MCM complex

Protein Structure and Domains

PDB ID

MGI:105380

InterPro

IPR000523 Magnesium chelatase, ChlI subunit
IPR001208 Mini-chromosome maintenance, DNA-dependent ATPase
IPR008045 DNA replication licensing factor Mcm2
IPR011703 ATPase, AAA-3
IPR011704 ATPase, dynein-related, AAA domain
IPR012340 Nucleic acid-binding, OB-fold
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01078
PF00493
PF12619
PF07726
PF07728

PRINTS

PR01657
PR01658

PIRSF

SMART

SM00350

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt