Version 5.4
Mus musculus Protein: Serpina12
Summary
InnateDB Protein IDBP-167755.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Serpina12
Protein Name serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
Synonyms 4632419J12Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000045572
InnateDB Gene IDBG-167753 (Serpina12)
Protein Structure
UniProt Annotation
Function Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues. {ECO:0000269PubMed:16030142, ECO:0000269PubMed:23370777}.
Subcellular Localization Secreted {ECO:0000269PubMed:23370777}.
Disease Associations
Tissue Specificity Expressed in visceral adipose tissues. {ECO:0000269PubMed:16030142}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
Cellular Component
GO:0005575 cellular_component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:1915304
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7TMF5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 68054
UniGene Mm.20286
RefSeq NP_080811
MGI ID
MGI Symbol Serpina12
OMIM
CCDS CCDS26145
HPRD
IMGT
EMBL AK014346 AK014589 AY326419
GenPept AAP88383 BAB29287 BAB29447

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca