InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Phox2b

Summary

InnateDB Protein

IDBP-167761.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Phox2b

Protein Name

paired-like homeobox 2b

Synonyms

Dilp1; NBPhox; Pmx2b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000012664

InnateDB Gene

IDBG-167759 (Phox2b)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001764	neuron migration
GO:0002087	regulation of respiratory gaseous exchange by neurological system process
GO:0003357	noradrenergic neuron differentiation
GO:0003358	noradrenergic neuron development
GO:0003360	brainstem development
GO:0006355	regulation of transcription, DNA-templated
GO:0008285	negative regulation of cell proliferation
GO:0010001	glial cell differentiation
GO:0010468	regulation of gene expression
GO:0021533	cell differentiation in hindbrain
GO:0021723	medullary reticular formation development
GO:0021934	hindbrain tangential cell migration
GO:0030182	neuron differentiation
GO:0035914	skeletal muscle cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048468	cell development
GO:0048483	autonomic nervous system development
GO:0048484	enteric nervous system development
GO:0048485	sympathetic nervous system development
GO:0048486	parasympathetic nervous system development
GO:0048839	inner ear development
GO:0048894	efferent axon development in a lateral line nerve
GO:0060541	respiratory system development
GO:0061452	retrotrapezoid nucleus neuron differentiation
GO:0061549	sympathetic ganglion development
GO:0071542	dopaminergic neuron differentiation
GO:0071773	cellular response to BMP stimulus
GO:1901166	neural crest cell migration involved in autonomic nervous system development