Version 5.4
Mus musculus Protein: Tbcb
Summary
InnateDB Protein IDBP-168148.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbcb
Protein Name tubulin folding cofactor B
Synonyms 2410007D12Rik; AU041393; CG22; Ckap1; CKAPI;
Species Mus musculus
Ensembl Protein ENSMUSP00000006254
InnateDB Gene IDBG-168146 (Tbcb)
Protein Structure
UniProt Annotation
Function Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (By similarity). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. {ECO:0000250, ECO:0000269PubMed:17184771, ECO:0000269PubMed:17217416}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17217416}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:17217416}. Note=Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone.
Disease Associations
Tissue Specificity Widely expressed with highest levels in brain. Broadly distributed throughout the neonate brain but restricted mainly to ependymary cells in the adult brain where it is concentrated in the cilia. {ECO:0000269PubMed:17217416}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007399 nervous system development
GO:0030154 cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005874 microtubule
Protein Structure and Domains
PDB ID MGI:1913661
InterPro IPR000938 CAP Gly-rich domain
IPR029071 Ubiquitin-related domain
PFAM PF01302
PRINTS
PIRSF
SMART SM01052
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D1E6
PhosphoSite PhosphoSite-Q9D1E6
TrEMBL
UniProt Splice Variant
Entrez Gene 66411
UniGene Mm.27947
RefSeq NP_079824
MGI ID 1WHG
MGI Symbol Tbcb
OMIM
CCDS CCDS21083
HPRD
IMGT
EMBL AK002316 AK003655 AK010438 BC010684
GenPept AAH10684 BAB22009 BAB22918 BAB26939

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca