InnateDB Protein
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IDBP-168199.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Nkx2-3
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Protein Name
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NK2 transcription factor related, locus 3 (Drosophila)
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Synonyms
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Nkx-2.3; Nkx2.3; tinman;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000050933
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InnateDB Gene
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IDBG-168197 (Nkx2-3)
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Protein Structure
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Function |
Transcriptional regulator essential for normal development and functions of the small intestine and spleen. Activates directly MADCAM1 expression. Required for homing of lymphocytes in spleen and mucosa-associated lymphoid tissue. May have a role during pharyngeal organogenesis. {ECO:0000269PubMed:10790368}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in spleen and intestine. Also expressed in salivary gland and tongue. {ECO:0000269PubMed:12141427}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:97348
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InterPro |
IPR001356
Homeobox domain
IPR009057
Homeodomain-like
IPR020479
Homeodomain, metazoa
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PFAM |
PF00046
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PRINTS |
PR00024
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PIRSF |
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SMART |
SM00389
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TIGRFAMs |
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Modification |
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SwissProt |
P97334
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PhosphoSite |
PhosphoSite-P97334
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
18089
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UniGene |
Mm.56994
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RefSeq |
NP_032725
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MGI ID |
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MGI Symbol |
Nkx2-3
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OMIM |
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CCDS |
CCDS29833
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HPRD |
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IMGT |
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EMBL |
AF155583
AF202036
BC072614
Y11117
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GenPept |
AAD38415
AAF08008
AAH72614
CAA72002
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