InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gsc

Summary

InnateDB Protein

IDBP-168339.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gsc

Protein Name

goosecoid homeobox

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021513

InnateDB Gene

IDBG-168337 (Gsc)

Protein Structure

UniProt Annotation

Function

Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis (By similarity). In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Goosecoid-expressing regions of the gastrulating mouse egg cylinder have organizer-like activity when transplanted into Xenopus embryos. Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

In early gastrulation, expressed in the dorsal lip. In later stages of development found in head, limbs and body wall. In the embryo, expressed in the postotic cranial neural crest cells, the frontonasal prominence, the first branchial arch and cleft, and specific regions of large joints. {ECO:0000269PubMed:24290375}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0009653	anatomical structure morphogenesis
GO:0014036	neural crest cell fate specification
GO:0021904	dorsal/ventral neural tube patterning
GO:0023019	signal transduction involved in regulation of gene expression
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030900	forebrain development
GO:0042474	middle ear morphogenesis
GO:0043583	ear development
GO:0048644	muscle organ morphogenesis
GO:0048704	embryonic skeletal system morphogenesis