InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mcat

Summary

InnateDB Protein

IDBP-168348.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mcat

Protein Name

malonyl CoA:ACP acyltransferase (mitochondrial)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051569

InnateDB Gene

IDBG-168346 (Mcat)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of a malonyl moiety from malonyl- CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity
GO:0016740	transferase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006633	fatty acid biosynthetic process
GO:0008152	metabolic process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

MGI:2388651

InterPro

IPR014043 Acyl transferase
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR016036 Malonyl-CoA ACP transacylase, ACP-binding
IPR020801 Polyketide synthase, acyl transferase domain

PFAM

PF00698

PRINTS

PIRSF

SMART

SM00827

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R3F5