InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Canx

Summary

InnateDB Protein

IDBP-168593.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Canx

Protein Name

calnexin

Synonyms

1110069N15Rik; AI988026; Cnx; D11Ertd153e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020637

InnateDB Gene

IDBG-168591 (Canx)

Protein Structure

UniProt Annotation

Function

Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at the synapse. {ECO:0000269PubMed:21747946, ECO:0000269PubMed:7628443}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:7628443}; Single-pass type I membrane protein {ECO:0000269PubMed:7628443}. Endoplasmic reticulum {ECO:0000250}. Melanosome {ECO:0000250}. Note=The palmitoylated form preferentially localizes to the perinuclear rough ER (By similarity). When bound to CD3 epsilon chains, calnexin's ER retention signal can be masked, permitting it to escape ER retention. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0034185	apolipoprotein binding
GO:0035255	ionotropic glutamate receptor binding
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0007568	aging
GO:0048488	synaptic vesicle endocytosis
GO:0061077	chaperone-mediated protein folding
GO:0072583	clathrin-mediated endocytosis

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005790	smooth endoplasmic reticulum
GO:0005791	rough endoplasmic reticulum
GO:0005840	ribosome
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0032839	dendrite cytoplasm
GO:0042470	melanosome
GO:0043025	neuronal cell body
GO:0043197	dendritic spine
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane