InnateDB Protein
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IDBP-168816.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Fev
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Protein Name
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FEV (ETS oncogene family)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000070878
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InnateDB Gene
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IDBG-168814 (Fev)
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Protein Structure
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Function |
Functions as a transcriptional regulator. May function as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth. {ECO:0000269PubMed:12546819, ECO:0000269PubMed:14602809, ECO:0000269PubMed:17656160}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00237, ECO:0000269PubMed:11875656}.
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Disease Associations |
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Tissue Specificity |
Expressed in central serotonergic neurons. {ECO:0000269PubMed:11875656}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0000981
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sequence-specific DNA binding RNA polymerase II transcription factor activity
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GO:0003690
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double-stranded DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
GO:0006355
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regulation of transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0010628
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positive regulation of gene expression
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GO:0042551
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neuron maturation
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0048665
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neuron fate specification
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Cellular Component |
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PDB ID |
MGI:2449712
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InterPro |
IPR000418
Ets domain
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PFAM |
PF00178
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PRINTS |
PR00454
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PIRSF |
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SMART |
SM00413
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TIGRFAMs |
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Modification |
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SwissProt |
Q8QZW2
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PhosphoSite |
PhosphoSite-
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TrEMBL |
E0CXR7
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UniProt Splice Variant |
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Entrez Gene |
260298
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UniGene |
Mm.150496
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RefSeq |
NP_694751
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MGI ID |
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MGI Symbol |
Fev
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OMIM |
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CCDS |
CCDS15058
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HPRD |
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IMGT |
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EMBL |
AC139023
AY049085
AY049086
BC138435
BC138436
CH466548
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GenPept |
AAI38436
AAI38437
AAL13055
AAL13056
EDL00354
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