InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adamts2

Summary

InnateDB Protein

IDBP-168909.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adamts2

Protein Name

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040171

InnateDB Gene

IDBG-168907 (Adamts2)

Protein Structure

UniProt Annotation

Function

Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0008233	peptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0007283	spermatogenesis
GO:0016485	protein processing
GO:0030199	collagen fibril organization
GO:0030324	lung development
GO:0030574	collagen catabolic process
GO:0043588	skin development

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:1347356

InterPro

IPR000884 Thrombospondin, type 1 repeat
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR002870 Peptidase M12B, propeptide
IPR010294 ADAM-TS Spacer 1
IPR010909 PLAC
IPR013273 Peptidase M12B, ADAM-TS
IPR013275 Peptidase M12B, ADAM-TS2

PFAM

PF00090
PF01421
PF01562
PF05986
PF08686

PRINTS

PR01857
PR01859

PIRSF

SMART

SM00209

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt