InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sult4a1

Summary

InnateDB Protein

IDBP-168993.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sult4a1

Protein Name

sulfotransferase family 4A, member 1

Synonyms

2400007A17Rik; AI853543; BR-STL-1; ST4A1; Sultx3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080973

InnateDB Gene

IDBG-168991 (Sult4a1)

Protein Structure

UniProt Annotation

Function

Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS. {ECO:0000269PubMed:12039030}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, cerebellum and hypothalamus. Not detected in pancreas, liver, lung, intestine, kidney, uterus, adrenal gland, thymus, spleen, epididymis, testicle, and heart. {ECO:0000269PubMed:12039030}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008146	sulfotransferase activity

Biological Process

GO:0006790	sulfur compound metabolic process
GO:0008202	steroid metabolic process

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1888971

InterPro

IPR000863 Sulfotransferase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00685

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P63046

PhosphoSite

PhosphoSite-P63046

TrEMBL

UniProt Splice Variant

Entrez Gene

29859

UniGene

Mm.422238

RefSeq

NP_038901

MGI ID

MGI Symbol

Sult4a1

OMIM

CCDS

CCDS27708

HPRD

IMGT

EMBL

AF059257 AK003034 AK010293 AK159034 BC051132 BC054757

GenPept

AAC63999 AAH51132 AAH54757 BAB22522 BAB26829 BAE34779