InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wnt7a

Summary

InnateDB Protein

IDBP-170092.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wnt7a

Protein Name

wingless-related MMTV integration site 7A

Synonyms

AI849442; px; tw; Wnt-7a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032180

InnateDB Gene

IDBG-170090 (Wnt7a)

Protein Structure

UniProt Annotation

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts. {ECO:0000269PubMed:9790192}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Note=Male mice lacking Wnt7a fail to undergo regression of the Mullerian duct as a result of the absence of the receptor for Mullerian-inhibiting substance. Wnt7a deficient females are infertile because of abnormal development of the oviduct and uterus, both of which are mullerian duct derivatives.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	3 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005125	cytokine activity
GO:0005515	protein binding

Biological Process

GO:0000578	embryonic axis specification
GO:0001502	cartilage condensation
GO:0002062	chondrocyte differentiation
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0007269	neurotransmitter secretion
GO:0007275	multicellular organismal development
GO:0008105	asymmetric protein localization
GO:0008284	positive regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0009953	dorsal/ventral pattern formation
GO:0014719	satellite cell activation
GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0016055	Wnt signaling pathway
GO:0021707	cerebellar granule cell differentiation
GO:0021846	cell proliferation in forebrain
GO:0022009	central nervous system vasculogenesis
GO:0030010	establishment of cell polarity
GO:0030326	embryonic limb morphogenesis
GO:0031133	regulation of axon diameter
GO:0032355	response to estradiol
GO:0035019	somatic stem cell maintenance
GO:0035115	embryonic forelimb morphogenesis
GO:0035116	embryonic hindlimb morphogenesis
GO:0035567	non-canonical Wnt signaling pathway
GO:0035659	Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells
GO:0042060	wound healing
GO:0042127	regulation of cell proliferation
GO:0042733	embryonic digit morphogenesis
GO:0043066	negative regulation of apoptotic process
GO:0043627	response to estrogen
GO:0045165	cell fate commitment
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046330	positive regulation of JNK cascade
GO:0048103	somatic stem cell division
GO:0048864	stem cell development
GO:0050768	negative regulation of neurogenesis
GO:0050770	regulation of axonogenesis
GO:0050808	synapse organization
GO:0051216	cartilage development
GO:0051965	positive regulation of synapse assembly
GO:0060021	palate development
GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing
GO:0060065	uterus development
GO:0060066	oviduct development
GO:0060070	canonical Wnt signaling pathway
GO:0060173	limb development
GO:0061038	uterus morphogenesis
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0009986	cell surface
GO:0031012	extracellular matrix