InnateDB Protein
|
IDBP-170115.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Hnrnpab
|
Protein Name
|
heterogeneous nuclear ribonucleoprotein A/B
|
Synonyms
|
3010025C11Rik; CBF-A; Cgbfa; Hnrpab;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000074238
|
InnateDB Gene
|
IDBG-170113 (Hnrnpab)
|
Protein Structure
|
|
Function |
Transcriptional repressor. Binds to CArG box motifs, single-stranded and double-stranded DNA, and RNA. It may be that repression by CBF-A is a result of competitive binding of CBF, a putative positive factor, and CBF-A to the same or overlapping motifs around the CArG boxes.
|
Subcellular Localization |
Nucleus {ECO:0000305}. Cytoplasm {ECO:0000250}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Ubiquitous.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Experimentally validated |
Total |
23
[view]
|
Protein-Protein |
21
[view]
|
Protein-DNA |
0
|
Protein-RNA |
2
[view]
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
47 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0000122
|
negative regulation of transcription from RNA polymerase II promoter
|
GO:0001837
|
epithelial to mesenchymal transition
|
GO:0006351
|
transcription, DNA-templated
|
GO:0045893
|
positive regulation of transcription, DNA-templated
|
|
Cellular Component |
|
PDB ID |
MGI:1330294
|
InterPro |
IPR000504
RNA recognition motif domain
IPR012956
CARG-binding factor, N-terminal
|
PFAM |
PF00076
PF08143
|
PRINTS |
|
PIRSF |
|
SMART |
SM00360
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q99020
|
PhosphoSite |
PhosphoSite-Q99020
|
TrEMBL |
Q544Z3
|
UniProt Splice Variant |
|
Entrez Gene |
15384
|
UniGene |
Mm.280842
|
RefSeq |
NP_034578
|
MGI ID |
|
MGI Symbol |
Hnrnpab
|
OMIM |
|
CCDS |
CCDS24654
|
HPRD |
|
IMGT |
|
EMBL |
AK013384
AK076132
CH466575
D90151
DQ397822
L36663
|
GenPept |
AAA92146
ABD66225
BAA14181
BAB28821
BAC36208
EDL33663
|
|
|