Version 5.4
Mus musculus Protein: Oaz3
Summary
InnateDB Protein IDBP-170163.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Oaz3
Protein Name ornithine decarboxylase antizyme 3
Synonyms Az-3; AZ3; Oaz-t;
Species Mus musculus
Ensembl Protein ENSMUSP00000029787
InnateDB Gene IDBG-170161 (Oaz3)
Protein Structure
UniProt Annotation
Function Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to ODC1 without promoting its degradation (PubMed:18508777, PubMed:16916800, PubMed:18973822). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:18062773). Involved in the translocation of AZNI2 from ER- Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:19449338). Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells. {ECO:0000269PubMed:16916800, ECO:0000269PubMed:18062773, ECO:0000269PubMed:18508777, ECO:0000269PubMed:18973822, ECO:0000269PubMed:19449338, ECO:0000269PubMed:24967154}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15642376}. Cytoplasm {ECO:0000269PubMed:15642376}.
Disease Associations
Tissue Specificity Testis specific. Expressed throughout the differentiation process from spermatids to spermatozoa in the inner part of the seminiferous tubules. {ECO:0000269PubMed:18973822}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004857 enzyme inhibitor activity
GO:0005515 protein binding
GO:0008073 ornithine decarboxylase inhibitor activity
GO:0071532 ankyrin repeat binding
Biological Process
GO:0006595 polyamine metabolic process
GO:0043086 negative regulation of catalytic activity
GO:0043666 regulation of phosphoprotein phosphatase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0036126 sperm flagellum
Protein Structure and Domains
PDB ID MGI:1858170
InterPro IPR002993 Ornithine decarboxylase antizyme
IPR016181 Acyl-CoA N-acyltransferase
PFAM PF02100
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9R109
PhosphoSite PhosphoSite-NP_058597
TrEMBL
UniProt Splice Variant
Entrez Gene 53814
UniGene Mm.440422
RefSeq
MGI ID
MGI Symbol Oaz3
OMIM
CCDS
HPRD
IMGT
EMBL AB016275 AF175297
GenPept AAD51735 BAA81913

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca