InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lsm6

Summary

InnateDB Protein

IDBP-170211.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lsm6

Protein Name

LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)

Synonyms

1500031N17Rik; 2410088K19Rik; AI747288;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049722

InnateDB Gene

IDBG-170209 (Lsm6)

Protein Structure

UniProt Annotation

Function

Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006364	rRNA processing
GO:0006397	mRNA processing
GO:0008033	tRNA processing
GO:0008380	RNA splicing

Cellular Component

GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1925901

InterPro

IPR001163 Ribonucleoprotein LSM domain
IPR006649 Ribonucleoprotein LSM domain, eukaryotic/archaea-type
IPR010920 Like-Sm (LSM) domain

PFAM

PF01423

PRINTS

PIRSF

SMART

SM00651

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P62313

PhosphoSite

PhosphoSite-P62313

TrEMBL

Q542U7

UniProt Splice Variant

Entrez Gene

78651

UniGene

Mm.415220

RefSeq

NP_084421

MGI ID

MGI Symbol

Lsm6

OMIM

CCDS

CCDS40396

HPRD

IMGT

EMBL

AK019126 AK078392 AK141884 AK158236 AK161686 BC030427 BC098230 BC099484 CH466525

GenPept

AAH30427 AAH98230 AAH99484 BAB31555 BAC37251 BAE24870 BAE34418 BAE36530 EDL10862 EDL10864