InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dhcr24

Summary

InnateDB Protein

IDBP-170298.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dhcr24

Protein Name

24-dehydrocholesterol reductase

Synonyms

2310076D10Rik; 5830417J06Rik; mKIAA0018;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038063

InnateDB Gene

IDBG-170296 (Dhcr24)

Protein Structure

UniProt Annotation

Function

Catalyzes the reduction of the delta-24 double bond of sterol intermediates. {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0008762	UDP-N-acetylmuramate dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0019899	enzyme binding
GO:0042605	peptide antigen binding
GO:0050614	delta24-sterol reductase activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0006979	response to oxidative stress
GO:0007265	Ras protein signal transduction
GO:0008104	protein localization
GO:0008202	steroid metabolic process
GO:0008203	cholesterol metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0009725	response to hormone
GO:0009888	tissue development
GO:0016125	sterol metabolic process
GO:0030539	male genitalia development
GO:0031639	plasminogen activation
GO:0042987	amyloid precursor protein catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043588	skin development
GO:0055114	oxidation-reduction process
GO:0061024	membrane organization

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0016020	membrane
GO:0016021	integral component of membrane