InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Peo1

Summary

InnateDB Protein

IDBP-170424.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Peo1

Protein Name

progressive external ophthalmoplegia 1 (human)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026227

InnateDB Gene

IDBG-170422 (Peo1)

Protein Structure

UniProt Annotation

Function

Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function infered to be critical for lifetime maintenance of mtDNA integrity. May be a key regulator of mtDNA copy number in mammals. {ECO:0000269PubMed:15509589}.

Subcellular Localization

Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250}. Note=Colocalizes with mtDNA in mitochondrial nucleoids, a nucleoproteins complex consisting of a number of copies of proteins associated with mtDNA, probably involved in mtDNA maintenance and expression. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous with the highest levels in the liver, heart and kidneys. The skeletal muscle, brain and testis showed lower but detectable expression. Expression is coregulated with MRPL43. {ECO:0000269PubMed:15509589}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0003678	DNA helicase activity
GO:0003697	single-stranded DNA binding
GO:0005524	ATP binding
GO:0043139	5'-3' DNA helicase activity

Biological Process

GO:0006260	DNA replication
GO:0006264	mitochondrial DNA replication
GO:0006268	DNA unwinding involved in DNA replication
GO:0006390	transcription from mitochondrial promoter
GO:0034214	protein hexamerization
GO:0051260	protein homooligomerization

Cellular Component

GO:0005739	mitochondrion
GO:0042645	mitochondrial nucleoid

Protein Structure and Domains

PDB ID

MGI:2137410

InterPro

IPR007694 DNA helicase, DnaB-like, C-terminal
IPR014774 Circadian clock protein KaiC/DNA repair protein RadA
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF03796
PF06745

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CIW5

PhosphoSite