InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mmaa

Summary

InnateDB Protein

IDBP-170481.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mmaa

Protein Name

methylmalonic aciduria (cobalamin deficiency) type A

Synonyms

2810018E08Rik; AI840684;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048826

InnateDB Gene

IDBG-170479 (Mmaa)

Protein Structure

UniProt Annotation

Function

Probable GTPase. May function as chaperone. May be involved in the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003674	molecular_function
GO:0005525	GTP binding
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0008150	biological_process
GO:0009236	cobalamin biosynthetic process

Cellular Component

GO:0005575	cellular_component
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:1923805

InterPro

IPR003495 CobW/HypB/UreG domain
IPR003593 AAA+ ATPase domain
IPR005129 ArgK protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02492
PF03308

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8C7H1

PhosphoSite

PhosphoSite-Q8C7H1

TrEMBL

UniProt Splice Variant

Entrez Gene

109136

UniGene

Mm.471134

RefSeq

NP_598584

MGI ID

MGI Symbol

Mmaa

OMIM

CCDS

CCDS22436

HPRD

IMGT

EMBL

AK050255 BC021954 BC027398

GenPept

AAH21954 AAH27398 BAC34149