InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hapln1

Summary

InnateDB Protein

IDBP-170843.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hapln1

Protein Name

hyaluronan and proteoglycan link protein 1

Synonyms

BB099155; CLP; Crtl1; Crtl1l; LP; LP-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022108

InnateDB Gene

IDBG-170841 (Hapln1)

Protein Structure

UniProt Annotation

Function

Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:12732630}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005540	hyaluronic acid binding

Biological Process

GO:0007155

cell adhesion

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:1337006

InterPro

IPR000538 Link
IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR016187 C-type lectin fold

PFAM

PF00193
PF07686

PRINTS

PR01265

PIRSF

SMART

SM00445
SM00406
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt