Version 5.4
Mus musculus Protein: Psmb4
Summary
InnateDB Protein IDBP-170874.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Psmb4
Protein Name proteasome (prosome, macropain) subunit, beta type 4
Synonyms Pros-27;
Species Mus musculus
Ensembl Protein ENSMUSP00000005923
InnateDB Gene IDBG-170872 (Psmb4)
Protein Structure
UniProt Annotation
Function The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal macrophage proteasome. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000255PROSITE- ProRule:PRU00809}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in liver (at protein level). {ECO:0000269PubMed:22341445}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 61 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0051603 proteolysis involved in cellular protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1098257
InterPro IPR001353 Proteasome, subunit alpha/beta
IPR016295 Proteasome endopeptidase complex, beta subunit
IPR029055 Nucleophile aminohydrolases, N-terminal
PFAM PF00227
PRINTS
PIRSF PIRSF001213
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P99026
PhosphoSite PhosphoSite-P99026
TrEMBL
UniProt Splice Variant
Entrez Gene 19172
UniGene Mm.408108
RefSeq NP_032971
MGI ID 3UNH
MGI Symbol Psmb4
OMIM
CCDS CCDS17597
HPRD
IMGT
EMBL AK077448 AK137044 AK156624 AK168265 AK168340 BC008241 M74556 U65636
GenPept AAA39863 AAC53263 AAH08241 BAC36805 BAE23215 BAE33781 BAE40213 BAE40277

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca