InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sgcb

Summary

InnateDB Protein

IDBP-171217.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sgcb

Protein Name

sarcoglycan, beta (dystrophin-associated glycoprotein)

Synonyms

43kDa; AI747103; AI844814; beta-SG;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079937

InnateDB Gene

IDBG-171215 (Sgcb)

Protein Structure

UniProt Annotation

Function

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Subcellular Localization

Cell membrane, sarcolemma {ECO:0000269PubMed:9864373}; Single-pass type II membrane protein {ECO:0000269PubMed:9864373}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:9864373}.

Disease Associations

Tissue Specificity

Most strongly expressed in skeletal and heart muscle. Also detected in proliferating myoblasts.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0007517	muscle organ development
GO:0048747	muscle fiber development
GO:0055013	cardiac muscle cell development
GO:0061024	membrane organization
GO:0097084	vascular smooth muscle cell development

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005887	integral component of plasma membrane
GO:0016010	dystrophin-associated glycoprotein complex
GO:0016011	dystroglycan complex
GO:0016012	sarcoglycan complex
GO:0016021	integral component of membrane
GO:0042383	sarcolemma