InnateDB Protein
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IDBP-171390.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ppp2r5c
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Protein Name
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protein phosphatase 2, regulatory subunit B (B56), gamma isoform
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Synonyms
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2610043M05Rik; 2700063L20Rik; AI060890; AW545884; C85228; D12Bwg0916e; mKIAA0044;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000082053
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InnateDB Gene
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IDBG-171384 (Ppp2r5c)
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Protein Structure
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Function |
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highest levels in heart, liver and brain. Lower levels in skeletal muscle, spleen, kidney and lung. Isoform 4 is testis-specific. {ECO:0000269PubMed:15051958}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
23 [view]
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Molecular Function |
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Biological Process |
GO:0006977
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DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
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GO:0007165
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signal transduction
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GO:0008285
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negative regulation of cell proliferation
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GO:0042771
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intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
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GO:0043161
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proteasome-mediated ubiquitin-dependent protein catabolic process
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GO:0050790
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regulation of catalytic activity
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Cellular Component |
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PDB ID |
MGI:1349475
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InterPro |
IPR002554
Protein phosphatase 2A, regulatory B subunit, B56
IPR016024
Armadillo-type fold
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PFAM |
PF01603
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PRINTS |
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PIRSF |
PIRSF028043
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q60996
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PhosphoSite |
PhosphoSite-Q60996
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
26931
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UniGene |
Mm.490988
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RefSeq |
NP_036153
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MGI ID |
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MGI Symbol |
Ppp2r5c
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OMIM |
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CCDS |
CCDS36557
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HPRD |
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IMGT |
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EMBL |
AB055635
AB055636
AY389498
BC003979
U37353
U59418
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GenPept |
AAB70857
AAC52435
AAH03979
AAR26474
BAB32447
BAB32448
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