InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Timm8a1

Summary

InnateDB Protein

IDBP-171396.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Timm8a1

Protein Name

translocase of inner mitochondrial membrane 8 homolog a1 (yeast)

Synonyms

Ddp1; DXHXS1274E; Fci-12; Tim8a; Timm8a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050156

InnateDB Gene

IDBG-171394 (Timm8a1)

Protein Structure

UniProt Annotation

Function

Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Intermembrane side {ECO:0000250}.

Disease Associations

Tissue Specificity

Present at high level in liver and brain, and at lower level in muscle and heart. In CNS sections, it is predominantly present in the soma and the dendritic portion of the Purkinje cells of the cerebellum, but not in the glial cells. Scattered expression also is also detected in the brain stem, olfactory bulb, substantia nigra, hippocampus and striatum (at protein level). Ubiquitously expressed. {ECO:0000269PubMed:10873677, ECO:0000269PubMed:15254020}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.