InnateDB Protein
|
IDBP-17147.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
CLEC6A
|
Protein Name
|
C-type lectin domain family 6, member A
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000371505
|
InnateDB Gene
|
IDBG-17145 (CLEC6A)
|
Protein Structure
|
|
Function |
Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9- NF-kappa-B-dependent pathway (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids. {ECO:0000269PubMed:15175046, ECO:0000269PubMed:15368084, ECO:0000269PubMed:15810886}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0043123
|
positive regulation of I-kappaB kinase/NF-kappaB signaling
|
GO:0045087
|
innate immune response (InnateDB)
|
GO:0050715
|
positive regulation of cytokine secretion
|
GO:0050832
|
defense response to fungus
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001304
C-type lectin
IPR002353
Type-2 ice-structuring protein
IPR016187
C-type lectin fold
|
PFAM |
PF00059
|
PRINTS |
PR00356
|
PIRSF |
|
SMART |
SM00034
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q6EIG7
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
93978
|
UniGene |
Hs.591147
|
RefSeq |
NP_001007034
|
HUGO |
HGNC:14556
|
OMIM |
613579
|
CCDS |
CCDS31739
|
HPRD |
16722
|
IMGT |
|
EMBL |
AC092746
AC092865
AY321309
AY365135
BC132933
BC132935
|
GenPept |
AAI32934
AAI32936
AAQ83725
AAR13071
|
|
|