InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnfaip8l2

Summary

InnateDB Protein

IDBP-171592.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfaip8l2

Protein Name

tumor necrosis factor, alpha-induced protein 8-like 2

Synonyms

1810019A08Rik; AW610835; TIPE2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000013851

InnateDB Gene

IDBG-171590 (Tnfaip8l2)

Protein Structure

UniProt Annotation

Function

Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis. {ECO:0000269PubMed:18455983}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in thymus, spleen, lymph node and small intestine, but not in liver, heart, muscle, testis, spinal cord or brain. Up-regulated in the spinal cord of mice with experimental autoimmune encephalomyelitis. Constitutively expressed by macrophages, B and T-lymphocytes at various developmental stages. {ECO:0000269PubMed:18455983}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0045087	innate immune response (InnateDB)
GO:0050728	negative regulation of inflammatory response
GO:0050868	negative regulation of T cell activation

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1917019

InterPro

IPR008477 Protein of unknown function DUF758

PFAM

PF05527

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D8Y7

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

69769

UniGene

Mm.34368

RefSeq

NP_081482

MGI ID

MGI Symbol

Tnfaip8l2

OMIM

CCDS

CCDS17603

HPRD

IMGT

EMBL

AF548004 AK007540 BC055879 BC094616

GenPept

AAH55879 AAH94616 AAQ12263 BAB25098