Version 5.4
Mus musculus Protein: Wdr18
Summary
InnateDB Protein IDBP-171740.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wdr18
Protein Name WD repeat domain 18
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000041049
InnateDB Gene IDBG-171738 (Wdr18)
Protein Structure
UniProt Annotation
Function May play a role during development (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. {ECO:0000250, ECO:0000269PubMed:22872859}.
Subcellular Localization Nucleus, nucleoplasm {ECO:0000269PubMed:22872859}. Cytoplasm {ECO:0000269PubMed:22872859}. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2158400
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF00400
PRINTS PR00320
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q4VBE8
PhosphoSite PhosphoSite-Q4VBE8
TrEMBL Q8K265
UniProt Splice Variant
Entrez Gene 216156
UniGene Mm.35828
RefSeq NP_780659
MGI ID
MGI Symbol Wdr18
OMIM
CCDS CCDS24000
HPRD
IMGT
EMBL AK133716 AK160713 AK168691 BC032968 BC095984
GenPept AAH32968 AAH95984 BAE21796 BAE35966 BAE40536

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca