InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ldb1

Summary

InnateDB Protein

IDBP-171766.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ldb1

Protein Name

LIM domain binding 1

Synonyms

CLIM2; NLI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053680

InnateDB Gene

IDBG-171764 (Ldb1)

Protein Structure

UniProt Annotation

Function

Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. {ECO:0000269PubMed:12150931, ECO:0000269PubMed:16815859, ECO:0000269PubMed:8876198, ECO:0000269PubMed:8918878, ECO:0000269PubMed:9192866, ECO:0000269PubMed:9315627, ECO:0000269PubMed:9391090}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:8876198, ECO:0000269PubMed:9315627, ECO:0000269PubMed:9391090}.

Disease Associations

Tissue Specificity

Expression overlaps that of LIM domain- containing proteins. Expressed widely in the embryo with highest expression in several regions of the brain the central nervous system ganglia. Also expressed in fetal liver, lung, kidney, thymus and olfactory epithelium. Expressed in multiple adult tissues including heart, brain, liver, kidney, testis, lung and muscle and a diverse range of neuronal cell types, with expression highest in the pituitary gland and skin. Expressed in both embryonic and adult hemopoietic cells, including the erythroid lineage. {ECO:0000269PubMed:16815859, ECO:0000269PubMed:8918878, ECO:0000269PubMed:9192866, ECO:0000269PubMed:9391090}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	33 [view]
Protein-DNA	20 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000989	transcription factor binding transcription factor activity
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001158	enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003712	transcription cofactor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0030274	LIM domain binding
GO:0042803	protein homodimerization activity
GO:0043621	protein self-association

Biological Process

GO:0000972	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
GO:0001702	gastrulation with mouth forming second
GO:0001942	hair follicle development
GO:0006366	transcription from RNA polymerase II promoter
GO:0009948	anterior/posterior axis specification
GO:0010669	epithelial structure maintenance
GO:0016055	Wnt signaling pathway
GO:0021549	cerebellum development
GO:0021702	cerebellar Purkinje cell differentiation
GO:0022607	cellular component assembly
GO:0030182	neuron differentiation
GO:0032784	regulation of DNA-templated transcription, elongation
GO:0035019	somatic stem cell maintenance
GO:0043973	histone H3-K4 acetylation
GO:0045647	negative regulation of erythrocyte differentiation
GO:0045785	positive regulation of cell adhesion
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046985	positive regulation of hemoglobin biosynthetic process
GO:0060319	primitive erythrocyte differentiation
GO:0060322	head development