InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mlc1

Summary

InnateDB Protein

IDBP-172020.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mlc1

Protein Name

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047667

InnateDB Gene

IDBG-172018 (Mlc1)

Protein Structure

UniProt Annotation

Function

Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008565	protein transporter activity
GO:0032403	protein complex binding

Biological Process

GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0032388	positive regulation of intracellular transport
GO:0047484	regulation of response to osmotic stress
GO:0051259	protein oligomerization
GO:0071397	cellular response to cholesterol
GO:0072584	caveolin-mediated endocytosis

Cellular Component

GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005768	endosome
GO:0005769	early endosome
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0005911	cell-cell junction
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome