Version 5.4
Mus musculus Protein: Eogt
Summary
InnateDB Protein IDBP-172023.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eogt
Protein Name RIKEN cDNA A130022J15 gene
Synonyms A130022J15Rik; Aer61; AI447490; AW214473; AW259391;
Species Mus musculus
Ensembl Protein ENSMUSP00000061610
InnateDB Gene IDBG-172021 (Eogt)
Protein Structure
UniProt Annotation
Function Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N- acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains. {ECO:0000269PubMed:22310717}.
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000255PROSITE-ProRule:PRU10138}.
Disease Associations
Tissue Specificity Widely expressed. Expressed in brain, heart, kidney, lung, skeletal muscles and thymus. Highest expression is observed in lung and the lowest in skeletal muscles. {ECO:0000269PubMed:22310717}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016262 protein N-acetylglucosaminyltransferase activity
GO:0016757 transferase activity, transferring glycosyl groups
Biological Process
GO:0006493 protein O-linked glycosylation
GO:0008152 metabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005788 endoplasmic reticulum lumen
Protein Structure and Domains
PDB ID MGI:2141669
InterPro IPR007657 Glycosyltransferase AER61, uncharacterised
PFAM PF04577
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BYW9
PhosphoSite PhosphoSite-
TrEMBL D3Z5Q3
UniProt Splice Variant
Entrez Gene 101351
UniGene Mm.486365
RefSeq NP_780522
MGI ID
MGI Symbol Eogt
OMIM
CCDS CCDS20383
HPRD
IMGT
EMBL AC155727 AK037507 BC048939
GenPept AAH48939 BAC29821

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca