InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnajb1

Summary

InnateDB Protein

IDBP-172273.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnajb1

Protein Name

DnaJ (Hsp40) homolog, subfamily B, member 1

Synonyms

0610007I11Rik; Hsp40; HSPF1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005620

InnateDB Gene

IDBG-172271 (Dnajb1)

Protein Structure

UniProt Annotation

Function

Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001671	ATPase activator activity
GO:0005515	protein binding
GO:0030544	Hsp70 protein binding
GO:0051082	unfolded protein binding
GO:0051087	chaperone binding
GO:0051117	ATPase binding

Biological Process

GO:0006457	protein folding
GO:0006950	response to stress
GO:0032781	positive regulation of ATPase activity
GO:0051085	chaperone mediated protein folding requiring cofactor
GO:0070389	chaperone cofactor-dependent protein refolding
GO:0090084	negative regulation of inclusion body assembly