InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gipc1

Summary

InnateDB Protein

IDBP-172303.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gipc1

Protein Name

GIPC PDZ domain containing family, member 1

Synonyms

GIPC; Glut1CIP; Rgs19ip1; Semcap1; TaxIP2; TIP-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019577

InnateDB Gene

IDBG-172301 (Gipc1)

Protein Structure

UniProt Annotation

Function

Inhibits endothelial cell migartion (in vitro). May be involved in G protein-linked signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:15527962}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005096	GTPase activator activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0017022	myosin binding
GO:0030165	PDZ domain binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006605	protein targeting
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007268	synaptic transmission
GO:0014047	glutamate secretion
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031647	regulation of protein stability
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032467	positive regulation of cytokinesis
GO:0043542	endothelial cell migration
GO:0043547	positive regulation of GTPase activity
GO:0048167	regulation of synaptic plasticity

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005903	brush border
GO:0005938	cell cortex
GO:0008021	synaptic vesicle
GO:0012506	vesicle membrane
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030139	endocytic vesicle
GO:0043197	dendritic spine
GO:0043198	dendritic shaft
GO:0070062	extracellular vesicular exosome