InnateDB Protein
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IDBP-172426.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ppt2
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Protein Name
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palmitoyl-protein thioesterase 2
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Synonyms
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0610007M19Rik; AA672937;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000068071
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InnateDB Gene
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IDBG-172422 (Ppt2)
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Protein Structure
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Function |
Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S- thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins (By similarity). {ECO:0000250}.
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Subcellular Localization |
Lysosome {ECO:0000269PubMed:14528005}.
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Disease Associations |
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Tissue Specificity |
Expressed throughout the brain, primarily in neurons, and at lower levels in glial cells. {ECO:0000269PubMed:11717424, ECO:0000269PubMed:14528005}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
24 [view]
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Molecular Function |
Accession |
GO Term |
GO:0008474
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palmitoyl-(protein) hydrolase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1860075
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InterPro |
IPR002472
Palmitoyl protein thioesterase
IPR029058
Alpha/Beta hydrolase fold
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PFAM |
PF02089
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PRINTS |
PR00414
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O35448
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PhosphoSite |
PhosphoSite-
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TrEMBL |
G5E8W7
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UniProt Splice Variant |
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Entrez Gene |
54397
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UniGene |
Mm.373627
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RefSeq |
XP_006524697
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MGI ID |
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MGI Symbol |
Ppt2
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OMIM |
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CCDS |
CCDS28652
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HPRD |
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IMGT |
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EMBL |
AF030001
BC013462
BC052330
CT009767
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GenPept |
AAB82011
AAH13462
AAH52330
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