InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Amn

Summary

InnateDB Protein

IDBP-172636.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Amn

Protein Name

amnionless

Synonyms

5033428N14Rik; AV002116;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021707

InnateDB Gene

IDBG-172634 (Amn)

Protein Structure

UniProt Annotation

Function

Necessary for efficient absorption of vitamin B12 (By similarity). May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm. {ECO:0000250, ECO:0000269PubMed:11279523, ECO:0000269PubMed:15342463, ECO:0000269PubMed:9851841}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in polarized epithelial cells which are specialized in resorption or transport, specifically kidney proximal tubules and intestinal epithelium. {ECO:0000269PubMed:15342463}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0007275	multicellular organismal development
GO:0007588	excretion
GO:0008104	protein localization
GO:0015889	cobalamin transport
GO:0043001	Golgi to plasma membrane protein transport

Cellular Component

GO:0005615	extracellular space
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030139	endocytic vesicle
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome