InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bex2

Summary

InnateDB Protein

IDBP-172816.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bex2

Protein Name

brain expressed X-linked 2

Synonyms

AL024066; Bex1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043113

InnateDB Gene

IDBG-172814 (Bex2)

Protein Structure

UniProt Annotation

Function

Regulator of mitochondrial apoptosis and G1 cell cycle. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Primarily localized to neuronal cells within several regions of the brain, including the olfactory epithelium, bulb, peri/paraventricular nuclei, suprachiasmatic nucleus, arcuate nucleus, median eminence, lateral hypothalamic area, thalamus, hippocampus and cerebellum (at protein level). {ECO:0000269PubMed:15861462}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006915	apoptotic process
GO:0007049	cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1338017

InterPro

IPR007623 Brain-expressed X-linked protein
IPR021156 Transcription elongation factor A-like/Brain expressed X-linked-like

PFAM

PF04538

PRINTS

PIRSF

PIRSF008633

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9WTZ8

PhosphoSite

PhosphoSite-Q9WTZ8

TrEMBL

UniProt Splice Variant

Entrez Gene

12069

UniGene

RefSeq

NP_033879

MGI ID

MGI Symbol

Bex2

OMIM

CCDS

CCDS30413

HPRD

IMGT

EMBL

AF097439 AK132005 BC027529

GenPept

AAD24430 AAH27529 BAE20934