InnateDB Protein
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IDBP-17286.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EIF4EBP1
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Protein Name
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eukaryotic translation initiation factor 4E binding protein 1
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Synonyms
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4E-BP1; 4EBP1; BP-1; PHAS-I;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000340691
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InnateDB Gene
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IDBG-17284 (EIF4EBP1)
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Protein Structure
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Function |
Regulates eIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269PubMed:22578813, ECO:0000269PubMed:7935836}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
49
[view]
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Protein-Protein |
49
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR008606
Eukaryotic translation initiation factor 4E binding
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PFAM |
PF05456
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q13541
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PhosphoSite |
PhosphoSite-Q13541
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
1978
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UniGene |
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RefSeq |
NP_004086
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HUGO |
HGNC:3288
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OMIM |
602223
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CCDS |
CCDS6100
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HPRD |
03746
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IMGT |
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EMBL |
AB044548
AK312011
BC004459
BC058073
BT007162
CH471080
CR456769
L36055
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GenPept |
AAA62269
AAH04459
AAH58073
AAP35826
BAB18650
BAG34949
CAG33050
EAW63341
EAW63342
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