InnateDB Protein
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IDBP-173035.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Bex1
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Protein Name
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brain expressed gene 1
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Synonyms
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AA407839; AU018692; Bex4; Rex3;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000060005
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InnateDB Gene
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IDBG-173033 (Bex1)
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Protein Structure
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Function |
Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:12911636}. Cytoplasm {ECO:0000269PubMed:12911636}. Note=Shuttles between the cytoplasm and the nucleus.
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Disease Associations |
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Tissue Specificity |
Primarily localized to neuronal cells within several regions of the brain, including the olfactory epithelium, bulb, peri/paraventricular nuclei, suprachiasmatic nucleus, arcuate nucleus, median eminence, lateral hypothalamic area, thalamus, hippocampus and cerebellum (at protein level). Expressed in brain, mid term embryos and to a lesser extent in ovary. In testis, it is expressed in the pachytene spermatocytes and spermatids but not in spermatogonia. {ECO:0000269PubMed:10072429, ECO:0000269PubMed:11989783, ECO:0000269PubMed:15861462, ECO:0000269PubMed:9806360}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1328321
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InterPro |
IPR007623
Brain-expressed X-linked protein
IPR021156
Transcription elongation factor A-like/Brain expressed X-linked-like
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PFAM |
PF04538
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PRINTS |
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PIRSF |
PIRSF008633
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9R224
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PhosphoSite |
PhosphoSite-Q9R224
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
19716
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UniGene |
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RefSeq |
NP_033078
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MGI ID |
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MGI Symbol |
Bex1
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OMIM |
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CCDS |
CCDS30417
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HPRD |
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IMGT |
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EMBL |
AF051347
AF097437
AF097438
AL671493
BC061179
BC089464
CH466616
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GenPept |
AAC61929
AAD24429
AAD47168
AAH61179
AAH89464
CAM45858
EDL23851
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