Version 5.4
Mus musculus Protein: Mum1
Summary
InnateDB Protein IDBP-173187.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mum1
Protein Name melanoma associated antigen (mutated) 1
Synonyms 2610019J09; 9430059D04Rik; UBE-1C2;
Species Mus musculus
Ensembl Protein ENSMUSP00000020365
InnateDB Gene IDBG-173185 (Mum1)
Protein Structure
UniProt Annotation
Function Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Recuited to DNA damage sites via its interaction with the BRCT domain of TP53BP1. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031491 nucleosome binding
Biological Process
GO:0006281 DNA repair
GO:0006325 chromatin organization
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1915364
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6DID5
PhosphoSite PhosphoSite-Q6DID5
TrEMBL D3Z468
UniProt Splice Variant
Entrez Gene 68114
UniGene Mm.409563
RefSeq NP_075920
MGI ID
MGI Symbol Mum1
OMIM
CCDS CCDS24014
HPRD
IMGT
EMBL AB030505 AC140229 AK078792 AK158750 AK170459 BC023031 BC069883 BC075617
GenPept AAH23031 AAH69883 AAH75617 BAA82658 BAC37397 BAE34640 BAE41811

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca